Active Pharmaceutical Ingredients co-crystals via solvent-free reactions

Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients.

The carboxylic acid-primary amide supramolecular heterosynthon is exploited for the generation of pharmaceutical co-crystals that contain two active pharmaceutical ingredients that are polymorphic in their pure forms.

New Trends in the Co-crystallization of Active Pharmaceutical Ingredients

Pharmaceutical materials science being a fundamental branch that continuously provides important insights, theories, and technologies to formulation sciences. The recent advances in this area have brought the possibility to produce pharmaceutical materials by design. In particular, the formation of co-crystals, i.e. crystalline molecular complexes of twoor more neutral molecules, represents a p...

Recrystallization of Active Pharmaceutical Ingredients

Quantitative analysis of active pharmaceutical ingredients (APIs)

Charge density and optical properties of multicomponent crystals containing active pharmaceutical ingredients or their analogues.

Active pharmaceutical ingredients (APIs), through their favourable donor/acceptor spatial distribution and synthon formation flexibility, are attractive building blocks in modern materials crystallography. The optical properties of a crystal strongly depend on two factors, i.e. the spatial distribution of molecules in the crystal structure and the electronic properties of molecular building blo...